Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
نویسندگان
چکیده
To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.
منابع مشابه
Atypical Scrapie Prions from Sheep and Lack of Disease in Transgenic Mice Overexpressing Human Prion Protein
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ورودعنوان ژورنال:
- Emerging Infectious Diseases
دوره 14 شماره
صفحات -
تاریخ انتشار 2008